Amikacin monotherapy for sepsis caused by panresistant Pseudomonas aeruginosa.

نویسندگان

  • Brice Layeux
  • Fabio Silvio Taccone
  • David Fagnoul
  • Jean-Louis Vincent
  • Frédérique Jacobs
چکیده

Two patients with severe sepsis due to panresistant Pseudomonas aeruginosa, deteriorating despite therapy with colistin and β-lactams, were cured with a high daily dose (25 to 50 mg/kg) of amikacin to obtain a peak/MIC ratio of at least 8 to 10 (MIC = 16 μg/ml). Concomitant use of continuous venovenous hemodiafiltration (CVVHDF) provided no deterioration in renal function after treatment. High dosage of aminoglycosides combined with CVVHDF may represent a valuable therapeutic option for infection due to multiresistant pathogens.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 54 11  شماره 

صفحات  -

تاریخ انتشار 2010